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Clopidogrel tablet dosage form with a manufacturer's recommended dosing interval of three or four weeks, with the possibility of shorter intervals during severe exacerbations of other underlying medical conditions. Clip-on-wax Clip-on-wax was developed in the mid-1990s response to desire control the recurrence of endometrial cancer after removal the ovary. Its use has improved but is still not widespread. In 1998, the FDA approved a low-volume dose, low-frequency (LR) injection regimen developed with the support of American College Obstetricians and Gynecologists the American College of Obstetricians and Gynecology Foundation. These two groups support using low-frequency, subcutaneous injections on the right ovary at 5 mg/day, followed by 1 mg/day until the patient's ovary is stimulated with low-frequency, subcutaneously implanted clopidogrel, 5 mg/day. During this initial period, the patient should be instructed to use a low-dose regimen for one year. Thereafter, in a 1–3 cycle, the low-frequency, subcutaneous implant clopidogrel subcutaneously given at 5 mg/day is used to induce ovulation and ovulate patients having a history of either recurrent endometriosis or unknown etiology. Other options for intrauterine exposure to prophylactic hormonal contraception include implants, intrauterine devices, transdermal contraceptives, topical and intrauterine injection; some of these options may be available in the U.S. FDA has also reviewed the options under consideration and is evaluating their use. For women with endometriosis who decide to be prescribed a low-volume, lower-frequency (LR, subcutaneous injections) regimen of oral clopidogrel (1 mg/day) for at least one year, they should read and comply with their provider's instructions about using the device appropriately. The patient also should be counseled to use transdermal patch (sold as LNG) consistently with the prescribed low-volume, low-frequency (LR, injection) regimen of clopidogrel (1 mg/day). The safety and effectiveness of these two hormonal options for treatment of endometriosis, in terms increased risk of blood clots, clots that are not responsive to anticoagulation, and the potential for serious adverse effects, should be weighed against the potential benefit for overall patient health and comfort with the treatment regimen. Progestin-only Combination Some patients who suffer a pelvic inflammatory disease can benefit from the combination of progestins containing 1 mg oestradiol and 15 of desogestrel daily to treat the primary or secondary endometriosis. Progestin-only vaginal gel (Provera, manufactured by Merck) is.
